Dr. Charles R. Sachatello, a retired physician, announced that he has published his revised and updated version of his Liver-Brain-Theory online.
Dr. Sachatello believes this is the single most comprehensive theory ever developed attempting to identify the inciting cause(s) and the reasons for the progressive course of neurodegenerative brain diseases, namely Alzheimer’s, Amyotrophic Lateral Sclerosis (ALS), Primary Dementia, (Non-Vascular Senile Dementias), Parkinson’s, Multiple Sclerosis and Age Related Macular Degeneration and any or all other forms of degenerative brain diseases currently without an established proximate cause
This multi year effort prompted Sachatello to propose that the degenerative brain diseases cited above have a common cause: “Neurotoxins generated in each patient’s own liver: Hepatic Generated Neurotoxins.”
Hepatic generated neurotoxins most likely derive from the inability of the patient’s own aging liver to completely metabolize the variety of common protein substrates it encounters during eating necessary to sustain life.
The great majority of these incompletely metabolized protein substrates are innocuous. Others could well have varying degrees of neurotoxicity. Specific neurotoxins will vary in the strength of their neurotoxicity, the quantity produced, their chemical composition, spatial configuration and structure accounting for the variety of different clinical manifestations characteristic of the variety of Neurodegenerative Brain Diseases referenced above.
Sachatello is acutely aware of the heretical nature of many of these currently preposterous ideas to the point that many can justifiably question his sanity. Nevertheless the basic premise of the Liver-Brain-Theory is easily testable.
The ultimate confirmation of this heretical theory is simple and straight forward.
A liver transplant (replacement) should preclude the further production of the specific hepatic generated neurotoxins leading to ALS resulting in total cessation in any further loss of muscle strength typically seen in patients with ALS resulting in a near normal life expectancy for many of these ALS afflicted patients.
A liver transplant will not be able to restore previously lost muscle strength or strengthen atrophied muscles in an ALS patient. A liver replacement should have minimal effect in altering the extent of memory loss in Alzheimer’s and Primary Dementia because of the extended prodromal course of these degenerative brain diseases.
The long term effect of a liver replacement in patients with Multiple Sclerosis is less certain due to the poorly understood biology of auto immune diseases.
If only a single patient with ALS is confirmed to have documented cessation of additional muscle loss following a liver transplant, the basic premise of the Liver-Brain-Theory will have been validated: “Hepatic generated neurotoxins are the proximate cause(s) of ALS”.
Confirmation of this theory should encourage others to concentrate on isolating and identifying the exact chemical composition and structural configuration of these specific hepatic generated neurotoxin(s).
A secondary corollary of the Liver-Brain-Theory is that nearly identical neurotoxins will be found to be the proximate cause(s) of most other forms of degenerative brain diseases including primary dementia.
Once the specific neurotoxin(s) causing ALS are identified with absolute certainty, worldwide attention must be directed to finding the nearly identical hepatic generated neurotoxins that Sachatello predicts will be confirmed to be the proximate cause of Alzheimer’s, Parkinson’s, Multiple Sclerosis and Age related Macular Degeneration. All subsequent research efforts should focus on studies of the spinal fluid, hepatocytes, glial cell cultures and brains of recently deceased patients with Alzheimer’s attempting to isolate and identify the specific Alzheimer neurotoxin(s).
This theory also predicts that it should be relatively easy to synthesize protein blocking or neutralizing agents which will be able to minimize or eliminate the neurotoxic effects of hepatic generated neurotoxins without the necessity of a liver replacement in the near future.
Similar blocking agents should be able to prevent further symptomatic progression of most other forms of degenerative brain diseases shortly thereafter.
"January 5, 2016
Dr. Charles Sachatello
I always enjoy hearing from you and especially reports about your liver-brain-theory. As you have emphasized, the ultimate test of the hypothesis would be liver replacement.
Thus, it would be very difficult, particularly in today’s climate to justify liver transplantation for the indication of ALS. Be that as it may, I continue to watch your initiatives with lively interest.
With best regards,
Thomas E. Starzl, M.D., Ph.D.
Professor of Surgery
Starzl Transplant Institute
University of Pittsburgh, Pittsburgh, PA"
Dr Starzl died March 4, 2017, a week shy of his 91st birthday. Although he was in failing health he sent me the above email only 14 months prior to his death. Dr. Starzl was my personal hero and he encouraged me to persist in refining these heretical ideas.
9/25/2016, Revised 5/7/2017, 6/10/2017, 8/1/2017, 10/22/2017, 11/14/2017, 3/8/2018
Charles R. Sachatello MD FACS
March 7, 2018