Formal Abstract
Section 02

"Proposed Conceptual and Unifying Theory"

"The glial-neuronal cell damage seen in Alzheimer’s, ALS, Primary Dementia, Parkinson’s , Multiple Sclerosis and Age Related Macular Degeneration most likely result from the inability of an aging, but histologically normal liver, to completely metabolize normal substrates encountered in the course of eating common foods in one’s normal daily life resulting in incompletely metabolized by products, some of which are neurotoxic".

These hepatic generated neurotoxins lead to initial glial-neuron cell degeneration, precipitating progressive glial-neuron cell death. The relative proportions of which specific neurotoxic metabolites are produced, could possibly determine whether any given patient develops ALS, Alzheimer’s, Primary Dementia, Parkinson’s, Multiple Sclerosis or Age Related Macular Degeneration or any or all other forms of neurodegenerative brain diseases known to exist.

Hepatic generated neurotoxins almost certainly will have different levels of neurotoxicity, and be produced in varying concentrations and quantities, accounting for the disparity in the rate of progression and clinical manifestations of various types of neurodegenerative brain diseases.

It is quite conceivable and very probable that hepatic generated neurotoxins are chemically and structurally similar to those that lead to hepatic encephalopathy, hepatic coma and death in patients with cirrhosis of the liver, independent of its proximate cause(s) in addition the specific clinical manifestations of any and all other forms of neurodegenerative brain diseases.

In plain and simple English, the Liver-Brain-Theory proposes that ”ALS, Alzheimer’s, Primary Dementias, Parkinson’s, Multiple Sclerosis and Age Related Macular Degeneration are closely related diseases, differing only in their clinical presentation and are the direct consequence of Neurotoxins Produced in each patient’s own Liver.” (Hepatic Generated Neurotoxins)

10/1/2014,   Rev: 2/15/2015 and multiple times thereafter -- 4/18/2017, 06/28/2017, 3/8/2018

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