Formal Abstract
Section 02

"Proposed Conceptual and Unifying Theory"

"The glial neuron cell damage seen in Alzheimer’s, ALS, Primary Dementia, Parkinson’s and age related macular degeneration result from the inability of an aging but histological normal liver to thoroughly metabolize common substrates encountered in the course of one’s normal daily life resulting in incompletely metabolized by products some of which are neurotoxic.

These hepatic generated neurotoxins are the proximate cause of the initial glial-neuron cell degeneration precipitating progressive glial-neuron cell death. The relative proportions, chemical composition and spatial configuration of specific neurotoxic metabolites could possibly determine whether any given patient develops: ALS, Alzheimer’s, Primary Dementia, Parkinson’s or age related macular degeneration.

Hepatic generated neurotoxins almost certainly will have different levels of neurotoxicity, and be produced in varying concentrations and quantities, accounting for the disparity in the rate of progression of the various types of neurodegenerative brain diseases.

It is quite conceivable and very probable that hepatic generated neurotoxins are structurally similar to those that lead to hepatic encephalopathy, progressive hepatic coma and death in patients with cirrhosis of the liver, independent of its proximate cause.

In plain and simple English, the “Liver-Brain-Theory” proposes that ALS, Alzheimer’s, Primary Dementia, Parkinson’s and age related macular degeneration and other types of neurodegenerative brain disease are the direct consequence of neurotoxins produced in each patient’s own liver.(Hepatic Generated Neurotoxins

10/1/2014,   Rev: 2/15/2015 and multiple times thereafter 4/9/2017-7/30/2018

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