"Man communicates via the written word.”
Nature abhors a vacuum: With the same intensity it abhors new ideas -(CRS)
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Amyotrophic Lateral Sclerosis (ALS), also known as Lou Gehrig’s disease, or “motor neuron disease” in Europe was initially described in a single patient in 1824 in London, England but definitively recognized as a distinct entity in 1867 by the French Neurologist, Jean-Martin Charcot. ALS was essentially unknown until 1939, when it afflicted Lou Gehrig, then one of the best recognized baseball players in the world. Gehrig died 25 months to the day he took himself out of the Yankee starting lineup “for the good of the team” at age 37. His death was the result of progressive muscle weakness typically seen in patients with ALS depriving him of the strength necessary to breathe and swallow.
Additionally, there are several million Americans with Nonvascular forms of senile dementias, (hereafter to be named: Primary Dementias) all without known cause or cure. These diseases are characterized by variable, but progressive loss of social skills and memory. A relatively high percent of patients with Primary Dementia insidiously progress to develop Alzheimer’s disease over a period of 5-10 years or longer. The variety of clinical findings present in patients with Primary Dementia is sufficiently variable and amorphous to preclude meaningful classification or enumeration.
Dr. Alzheimer publicly presented the clinical details of Auguste “D” Deter at a local medical meeting in Germany in 1907. Auguste “D” developed dramatic and progressive memory loss with associated erratic and psychotic behavior beginning in her forties. Also being trained as a pathologist, Dr. A was able to examine her brain 8 years later in 1915 as silver stains became available he recognized the nerve tangles diagnostic of his namesake disease. Alzheimer’s exists in an estimated 35-45 million patients in the world today including 5.2–5.4 million Americans. It continues to be the single most expensive disease to treat in view of the fact that nearly 100% of afflicted patients require terminal domiciliary nursing care for several years prior to their death. The Japanese government has estimated that the cost of caring for their patients with Alzheimer’s approximates 1% of their gross national product. (5 trillion US$ +/-)
The "Liver-Brain-Theory” is the single most comprehensive and testable theory ever developed. It is now published attempting to explain the origin(s) of any or all types of degenerative brain diseases known to exist.
The author openly predicts that many of these heretical ideas will prove relevant, if not prescient. Currently it is virtually impossible to find a reputable medical journal willing to publish any new ideas or theories relevant to neurodegenerative diseases: even a simple theory as short as 134 words in length was rejected by two prominent medical journals as recently as September, 2014.Even the ALS organization refused to publish or cite these heretical ideas pertinent to ALS, their primary reason to exist.
This web site will encourage and welcome other investigators an opportunity to publish their own ideas concerning any other possible causes of neurodegenerative diseases. Additionally this site will provide a public forum for other thoughtful and knowledgeable individuals to exchange ideas without concern of being ridiculed. Should we be able to reason together, more cogent and relevant theories pertinent to these debilitating diseases will most likely be developed within a year or two.
Despite the fact that physicians have been aware of ALS, an inevitably fatal disease, for nearly two hundred years & Alzheimer’s for 110 years, (more that 3 centuries in toto), no one including the: NIH, the National Institute of Nervous and Mental Diseases, the Alzheimer's or ALS Association, any reputable Medical Journal or any Neurology Group, Society or Organization has had the courage or knowledge to publish a testable theory accounting for the
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