The most straight forward, least expensive and simplest way to refute or validate the basic premise of this theory would entail the use of repetitive plasmapheresis. Repetitive plamapheresis in patients with ALS will curtail the rate of progression of muscle loss and weakness simply by reducing the quantity of circulating hepatic generated neurotoxins which I postulate to exist.
Even more important, the plasma removed from afflicted patients will provide a ready source for obtaining the specific hepatic generated neurotoxin(s) promoting the development of ALS. It should be quite easy to isolate and identify the specific hepatotoxins which will be shown to be the proximate cause of ALS.
This data confirming that the rate of loss of muscle strength in patients with ALS via repetitive plasmapheresis can be curtailed to an absolute minimum should provide sufficient evidence to warrant performing a liver transplant. A single liver transplant which demonstrates it can prevent progression of ALS will provide ultimate confirmation for the basic premise of the Liver-Brain-Theory.
Once the exact chemical composition of these specific hepatic generated neurotoxins are determined, it should be relatively easy to develop specific medications (neurotoxic blocking agents) precluding the progression of additional muscle weakness patients with ALS.
In my opinion, ALS will soon be treated as a chronic disease, just as diabetes is, whose progression can be blocked by a combination of dietary changes and ingestion of specific medication (neurotoxic blocking agents). Similar studies will lead to the development of specific blood tests to identify those individuals at risk to develop Alzheimer’s disease while they are still teenagers. Here too, it should be possible to develop similar medications precluding the onset of developing this terrible disease.